The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level
نویسندگان
چکیده
منابع مشابه
The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level.
BACKGROUND The role of C825T polymorphism of the candidate GNB3 gene in predicting cerebrovascular outcome has been poorly explored in longitudinal setting at a population level. METHODS In an epidemiological setting, 1,678 men and women from general population were genotyped for C825T polymorphism of GNB3 gene and follow-up for 10 years to detect nonfatal and fatal cerebrovascular events (CE...
متن کاملVasovagal syncope patients and the C825T GNB3 polymorphism.
OBJECTIVE The G protein is responsible for signal intracellular transduction and participates in cardiovascular reflexes. C825T polymorphism of the gene encodes the B3 subunit of G protein (GNB3) and causes the increased intracellular signal transduction. The aim was the evaluation GNB3 C825T polymorphism manifestation in vasovagal patients with no other diseases. METHODS In 68 positive tilte...
متن کاملCognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population
To verify whether the C825T polymorphism of the GNB3 influences the response to neuropsychological tests, mini-mental state examination, digit span (DS), immediate and delayed prose memory, memory with interference at 10 and 30 seconds (MI 10 and 30), trail making tests (TMTs) A and B, abstraction task, verbal fluency (VF) test, figure drawing and copying, overlapping figures test and clock tes...
متن کاملQuantitative assessment of the association between GNB3 C825T polymorphism and cancer risk.
PURPOSE The association between GNB3 C825T polymorphism and cancer risk has been investigated. However, results remain inconclusive. In this study we aimed to obtain a more precise estimation of this association. METHODS A meta-analysis of 8 eligible studies including 1,812 cancer cases and 3,731 controls was conducted with odds ratios (ORs) and the corresponding 95% confidence interval (95% ...
متن کاملPrediction of the Risk for Essential Hypertension among Carriers of C825T Genetic Polymorphism of G Protein β3 (GNB3) Gene
BACKGROUND The guanine nucleotide-binding protein beta polypeptide 3 (GNB3) 825T allele encodes a product that enhances the activation of heterotrimeric G proteins, which is associated with the occurrence of the splice variant Gβ3 s that could play a role in vascular reactivity and hyperproliferation of smooth muscle cells, that makes such proteins attractive candidate gene products for suscept...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2012
ISSN: 0895-7061,1941-7225
DOI: 10.1038/ajh.2011.257